Research on selective uptake of photosensitizer C₃N₄@RP by different cancer cells

Abstract Photodynamic therapy (PDT), as a clinical treatment, can remove malignant cells upon laser irradiation by selective uptake of photosensitizer (PS). The relative contribution these antitumor effects depends largely on the dose and PS. In this study, C 3 N 4 @RP was chosen candidate for studies different cancer cells. has been proved to possess excellent properties, including absorption edges extending up 700 nm, efficient cellular uptake, low cytotoxicity, favorable intracellular fluorescence localization. Considering optimal therapeutic effect, we first incubated concentrations PS with A549 HeLa in vitro observe efficiency at times. At concentration 20 μ g ml −1 , showed time-dependent accumulation. increasing accumulation most effective 24 h follows an order > A549. These results suggest that types have saturation times same All presented support idea properly designed is suitable specific time achieve best effect.